Large Capacity Freeze Dryer

Large Capacity Freeze Dryer – QualiFD™ L Series

The Large Capacity Freeze Dryer – QualiFD™ L Series is a floor-standing freeze dryer machine designed for high-throughput laboratory lyophilization where benchtop systems fall short. It supports applications across pharmaceuticals, life sciences, chemical analysis, and food processing labs that require expanded drying area and reliable daily processing capacity.

Built for flexibility, the system features integrated caster wheels for smooth relocation between lab zones, making it suitable for shared or multi-purpose environments. The integrated floor design supports consistent operation while offering an expandable drying area of up to 0.27 m² to meet increasing workload demands.

The cold trap and working surface are constructed from stainless steel to support efficient cleaning and long-term resistance to corrosion. Product-contact components are made from inert materials, aligning with GLP-focused laboratory practices.

A large cold-trap opening combined with a built-in pre-freeze function supports streamlined workflows without the need for a separate low-temperature freezer. The intuitive touchscreen controller provides real-time monitoring and data logging of cold trap temperature, sample temperature, and vacuum curves, helping maintain process visibility and documentation for each run.

Applications of QualiFD™ L Series Large Capacity Freeze Dryer

Pharmaceutical and Medical Research:
Freeze drying preserves APIs, excipients, and formulation trials that may degrade in solution. The top-press setup enables vial workflows, allowing vials to be stoppered under vacuum after drying. Logged process curves provide R&D teams with detailed cycle comparisons and documentation for consistent batch results.

Biology and Biotechnology:
The system supports lyophilization of biological samples and reagents for extended storage and easier transport. The ampoule-tube setup is optimized for microorganism preservation, including bacteria and fungi. With a larger-capacity platform, labs can process more samples per run while maintaining a controlled vacuum environment.

Chemistry and Materials Development:
Freeze drying allows gentle solvent removal for heat-sensitive compounds, suspensions, and porous materials. Manifold configurations support drying in multiple vessels simultaneously. Stainless steel cold traps and work surfaces simplify routine cleaning when working with common laboratory solvents.

Food and Ingredient R&D:
Ideal for pilot studies, freeze drying protects the texture, aroma, and composition of sensitive ingredients. The expanded tray area accommodates higher sample volumes for process development. Integrated mobility ensures a single unit can be shared efficiently across multiple R&D rooms or departments.

Standards and Compliance

The QualiFD™ L Series Large Capacity Freeze Dryer adheres to internationally recognized standards for safe and reliable laboratory operation:

• ISO 13408-3: Aseptic processing, Part 3 – Lyophilization
• ASTM E3250: Instrumentation best practices for pharmaceutical freeze drying
• IEC 61010-1: General safety requirements for laboratory electrical equipment

These certifications ensure the system meets rigorous quality, safety, and operational guidelines for pharmaceutical, biotechnology, and research applications.

Key Features – QualiFD™ L Series Large Capacity Freeze Dryer

• Integrated One-Piece Construction: Minimizes leak points and simplifies installation in laboratory environments.
• GLP-Focused Design: Product-contact components made from inert materials suitable for regulatory-compliant lab work.
• Stainless Steel Cold Trap and Work Surface: Enhances corrosion resistance and simplifies cleaning for routine use.
• All-Stainless Venting Valve: Designed to minimize leak risk and support safer operation.
• Pre-Freeze Workflow Support: Large cold-trap opening and pre-freezing functionality streamline sample preparation.
• Optimized Gas Flow Control: Improves ice capture uniformity within the cold trap.
• 7-Inch Touchscreen Controller: Displays real-time temperature, sample, and vacuum curves, with options to export for review, printing, and reporting.
• Built-In Alarms and Protection Logic: Monitors runtime, temperature, and component status to ensure safe and reliable operation.
• Electric Defrost Function: Reduces turnaround time between drying cycles.
• Caster-Wheel Base: Facilitates easy relocation across shared laboratory spaces.

Freeze Drying Theory and Method

Freeze drying removes water or solvent from a frozen product by applying a vacuum, allowing ice to sublimate directly into vapor without melting. A standard lyophilization cycle involves three main stages:

• Freezing: The product is frozen to form ice crystals, establishing the structure for controlled drying.
• Primary Drying (Sublimation): Under low pressure, ice transitions to vapor. Chamber pressure and cold-trap temperature influence the sublimation rate and capture efficiency. Continuous sample temperature monitoring ensures the product remains below its thermal limits.
• Secondary Drying (Desorption): Remaining bound moisture is reduced to achieve stable storage conditions.

Vapor is captured on the cold trap, and after the drying process, the chamber is safely vented to atmospheric pressure for product unloading and sealing. This controlled method preserves structure, activity, and quality of sensitive materials.

Large Capacity Freeze Dryer – QualiFD™ L Series Technical Specification

• QualiFD™ L1 (Standard): 4–6 stainless trays for bulk materials (liquid, paste, solid).
• QualiFD™ L2 (Top-Press): 3 trays with adjustable spacing; supports vial drying and vacuum stoppering after drying.
• QualiFD™ L3 (Standard + Multiple Manifolds): tray drying plus external hanging bottle attachment for vials or wide-mouth bottles; attachment can be removed during use.
• QualiFD™ L4 (Top-Press + Multiple Manifolds): combines top-press vial workflow with manifold capability.
• QualiFD™ L5 (Ampoule Tube): 24 ampoule interfaces for microorganism preservation workflows.

Full technical parameters

Specification	QualiFD™ L1	QualiFD™ L2	QualiFD™ L3	QualiFD™ L4	QualiFD™ L5
Configuration	Standard	Top-press	Standard + multiple manifolds	Top-press + multiple manifolds	Ampoule tube
Freeze drying area	0.18 / 0.27 m²	0.09 m²	0.18 / 0.27 m²	0.09 m²	—
Cold trap temperature	≤ -60 °C (optional ≤ -80 °C, ≤ -110 °C no-load)
Ultimate vacuum	< 5 Pa (no-load)
Water capture capacity	6 kg/24 h
Material tray	240 mm, 4 layers (optional 6)	200 mm, 3 layers	240 mm, 4 layers (optional 6)	200 mm, 3 layers	—
Overall power	1400 W
Main unit weight	105 kg
Dimensions (W×D×H)	630×580×970 mm + (445 drying chamber)	630×580×970 mm + (540 drying chamber)	630×580×970 mm + (445 drying chamber)	630×580×970 mm + (540 drying chamber)	630×580×970 mm + (440)
Loadable materials (10 mm thickness reference)	1.8 / 2.7 L	0.9 L	1.8 / 2.7 L	0.9 L	—
Loadable vials (tray reference)	Φ12: 615; Φ16: 345; Φ22: 183	Φ12: 615; Φ16: 345; Φ22: 183	—	—	—